← All companies ← IR Manual IRDM → ← IONS Pharmaceuticals IRWD →
IRD, Opus Genetics Inc.
Opus Genetics Inc. is a clinical-stage biopharmaceutical company developing gene therapies to restore vision and prevent blindness in patients with inherited retinal diseases, and other types of therapies for additional ophthalmic disorders.
Opus was founded in February 2018 as Ocuphire Pharma, Inc. and has since undergone the following transactions: In April 2018, Ocuphire Pharma, Inc. merged with Ocularis Pharma, LLC, the original innovator of phentolamine mesylate ophthalmic solution.
We are also advancing Phentolamine Ophthalmic Solution 0.75%, a small-molecule therapy that is FDA-approved for pharmacologically induced mydriasis, with additional potential indications in presbyopia and low-light visual disturbances following keratorefractive surgery.
The business
What it sells, where the money comes from, the kind of company it is.
The business in brief
read the 10-K →What this business is and what moves its needle, from its own SEC filings.
- Situation
- Unprofitable. No meaningful revenue yet; the record is the cash on hand against the burn.
- What moves the needle
- Operating margin has reached 46% at its best but run negative through the cycle (median −272%) — so the question is which reading is truer: whether the median was pulled below zero by one-off charges, by the cycle, or by spending it is still growing into, and whether it settles back at a profit. Stock-based pay runs about 18% of sales, a real and recurring claim on owners that the GAAP margin understates. Read this kind of business on the pipeline against the patent cliff, and pricing. On its own account, the filing leans hardest on pricing power & competition, set against the numbers in what the filing emphasizes, below.
Every line is arithmetic on the company's filings, shown in full in the sections below.
The record
Ten years of arithmetic, read across the cycle.
The record, 2011–2025
realized figures from each filing · older years to the left| 2011’11 | 2012’12 | 2013’13 | 2019’19 | 2020’20 | 2021’21 | 2022’22 | 2023’23 | 2024’24 | 2025’25 | TTMTTMMar 2026 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Income statement | |||||||||||
| $0 | $0 | $0 | $3M | $0 | $589K | $40M | $19M | $11M | $14M | $12M | RevenueRevenue |
| — | — | — | 61% | — | n/m | 18% | 63% | 166% | 155% | 180% | SG&A / revenueSG&A/rev |
| — | — | — | 183% | — | n/m | 36% | 93% | 244% | 217% | 279% | R&D / revenueR&D/rev |
| ($16M) | ($7M) | ($8M) | ($4M) | ($20M) | ($23M) | $18M | ($11M) | ($62M) | ($39M) | ($43M) | Operating incomeOp. inc. |
| — | — | — | −139.8% | — | n/m | 45.7% | −55.5% | −564.7% | −271.9% | −359.1% | Operating marginOp. mgn |
| ($11M) | ($6M) | ($9M) | ($6M) | ($25M) | ($57M) | $18M | ($10M) | ($58M) | ($50M) | ($107M) | Net incomeNet inc. |
| Cash flow & returns | |||||||||||
| ($16M) | ($7M) | ($8M) | ($4M) | ($7M) | ($19M) | $14M | ($1M) | ($26M) | ($35M) | ($39M) | Operating cash flowOp. cash |
| $45K | $42K | $37K | $41K | $8K | $4K | $4K | $6K | $10K | $53K | $53K | DepreciationDeprec. |
| ($5M) | ($666K) | $912K | $2M | $16M | $35M | ($5M) | $5M | $29M | $11M | $64M | Working capital & otherWC & other |
| $16K | — | $50K | $25K | $0 | — | — | — | — | — | $0 | CapexCapex |
| ($16M) | — | ($8M) | ($4M) | ($7M) | — | — | — | — | — | ($39M) | Owner earningsOwner earn. |
| ($16M) | — | ($8M) | ($4M) | ($7M) | — | — | — | — | — | ($39M) | Free cash flowFCF |
| -106% | -65% | -75% | — | — | -255% | 39% | -20% | -856% | -323% | — | Return on equityROE |
| −106% | −65% | −75% | — | — | −255% | 39% | −20% | −856% | −323% | — | Retained to equityRetained/eq |
| Balance sheet | |||||||||||
| $12M | $14M | $19M | $15M | $16M | $25M | $43M | $51M | $30M | $45M | $60M | Cash & investmentsCash+inv |
| — | — | — | — | — | $0 | $1M | $926K | $4M | $2M | $2M | ReceivablesReceiv. |
| $1M | $852K | $934K | $342K | $1M | $2M | $1M | $2M | $3M | $3M | $4M | Accounts payablePayables |
| — | — | — | — | — | ($2M) | $229K | ($1M) | $415K | ($1M) | ($3M) | Operating working capitalOper. WC |
| $12M | $14M | $19M | $2M | $18M | $26M | $49M | $54M | $37M | $50M | $67M | Current assetsCur. assets |
| — | — | — | $9M | $3M | $4M | $3M | $4M | $11M | $8M | $9M | Current liabilitiesCur. liab. |
| — | — | — | 0.2× | 5.5× | 6.8× | 17.8× | 13.3× | 3.2× | 6.4× | 7.1× | Current ratioCurr. ratio |
| $14M | $15M | $20M | $2M | $18M | $26M | $49M | $54M | $37M | $50M | $67M | Total assetsAssets |
| — | — | — | — | — | — | — | — | $0 | $1M | $1M | Total debtDebt |
| — | — | — | — | — | — | — | — | ($30M) | ($44M) | ($59M) | Net debt / (cash)Net debt |
| — | — | — | -3.0× | -2.9× | -11352.5× | 2025.1× | — | — | -299.2× | -217.3× | Interest coverageInt. cov. |
| $11M | $10M | $13M | ($8M) | ($13M) | $22M | $46M | $50M | $7M | $15M | ($46M) | Shareholders’ equityEquity |
| — | — | — | 10.3% | — | 325.0% | 4.5% | 18.4% | 30.6% | 23.9% | 33.0% | Stock comp / revenueSBC/rev |
| Per share | |||||||||||
| 93.0M | 97.1M | 129M | 2.8M | 4.7M | 14.9M | 20.6M | 21.6M | 26.7M | 62.2M | 86.9M | Shares out (diluted)Shares |
| $0.00 | $0.00 | $0.00 | $1.05 | $0.00 | $0.04 | $1.93 | $0.88 | $0.41 | $0.23 | $0.14 | Revenue / shareRev/sh |
| $-0.12 | $-0.06 | $-0.07 | $-2.17 | $-5.28 | $-3.82 | $0.87 | $-0.46 | $-2.15 | $-0.80 | $-1.23 | EPS (diluted)EPS |
| $-0.17 | — | $-0.06 | $-1.27 | $-1.46 | — | — | — | — | — | $-0.45 | Owner earnings / shareOE/sh |
| $-0.17 | — | $-0.06 | $-1.27 | $-1.46 | — | — | — | — | — | $-0.45 | Free cash flow / shareFCF/sh |
| $0.00 | — | $0.00 | $0.01 | $0.00 | — | — | — | — | — | $0.00 | Cap. spending / shareCapex/sh |
| $0.12 | $0.10 | $0.10 | $-2.66 | $-2.89 | $1.50 | $2.24 | $2.31 | $0.25 | $0.25 | $-0.53 | Book value / shareBVPS |
The diluted share count moved ×1/45.22 into 2019 — shares retired, not a split the totals corroborate — and the per-share figures carry the counts as filed.
The diluted share count moved ×1.64 into 2020 — shares issued, not a split the totals corroborate — and the per-share figures carry the counts as filed.
The diluted share count moved ×3.19 into 2021 — shares issued, not a split the totals corroborate — and the per-share figures carry the counts as filed.
The diluted share count moved ×2.33 into 2025 — shares issued, not a split the totals corroborate — and the per-share figures carry the counts as filed.
The record, charted
FY2011–2025Each measure over its full record; the current point and the worst year marked.
Owner earnings vs. net income
Owner earningsNet incomeThe accountant's number, and the cash an owner can take; the gap is the tell.
Net income is the accountant's number; owner earnings is the cash an owner could take out. The walk between them, off the cash-flow statement, and whether the gap is widening or holding.
In fiscal 2020 the business turned a $25M loss into ($7M) of owner earnings: more cash than the profit line showed, after the non-cash charges and the capital it put back in.
| FY2020 | FY2019 | FY2013 | FY2011 | |
|---|---|---|---|---|
| Reported net income | ($25M) | ($6M) | ($9M) | ($11M) |
| Depreciation & amortizationnon-cash charge added back | +$8K | +$41K | +$37K | +$45K |
| Stock-based compensationreal costnon-cash, but a real cost | +$2M | +$308K | +$565K | +$639K |
| Working capital & othertiming of cash in and out, other non-cash items | +$16M | +$2M | +$912K | −$5M |
| Cash from operations | ($7M) | ($4M) | ($8M) | ($16M) |
| Capital expenditurecash put back in to keep running and to grow | — | −$25K | −$50K | −$16K |
| Owner earnings | ($7M) | ($4M) | ($8M) | ($16M) |
| Owner-earnings marginowner earnings ÷ revenue | — | -121% | — | — |
Owner earnings is the cash an owner could pull out without starving the business: operating cash less the capital it must spend to hold its position . The cash-flow statement also adds stock comp back as non-cash, but it is a real cost paid in shares; counted as the expense it is (less $2M), owner earnings is nearer ($8M).
Maintenance capex is estimated as depreciation where a growing business invests above it; free cash flow is the figure the scorecard's free-cash margin reads.
Quality & stewardship
Returns, the balance sheet, capital allocation, and pay.
Owner’s Scorecard
Will it survive?
- Can it pay its interest? -299.2×Does not cover its interestOperating income ($39M) ÷ interest expense $129K
What this means
A full year of operating profit didn't cover the interest bill. This is the zombie zone: the business depends on refinancing, asset sales, or forbearance to service its debt.
- Net cashCash $45M − debt $1M
What this means
Cash and short-term investments exceed every dollar of debt by $44M, on net the company owes nothing, and can act from strength when others can't. Net debt is the leverage figure that matters: the cash is already set against the debt. Strategic or illiquid investments aren't counted here.
- Not enough data
What this means
The filing data didn't include the inputs for this check.
Is it a good business?
- Not meaningful hereInvested capital ($29M) = debt $1M + equity $15M − cashIndustry peers: median -86%
What this means
Invested capital is near zero or negative, usually years of buybacks pulling equity down. ROIC explodes or flips sign and stops meaning anything. Judge this one on Owner Earnings instead.
- Owner-earnings margin -248%Consumes cashOwner earnings ($35M) = operating cash ($35M) − maintenance capex $0Industry peers: median -605%
What this means
What an owner could take out without starving the business: operating cash less the maintenance capital it must spend to hold its position — Buffett's owner earnings. That's -248% of revenue this year. Treating stock comp as the real expense it is (less $3M of SBC) leaves ($39M).
- Are earnings backed by cash? ($35M)Loss, and burning cashNet income ($50M) · cash from operations ($35M)
What this means
The company reported a net loss, so a conversion ratio isn't meaningful. What matters then is whether operations still threw off cash, here, they did not.
How is the cash used?
- No surplus to allocate
What this means
The business didn't generate positive Owner Earnings this year, so any distributions came from the balance sheet or borrowing, not from operations.
- Investing or harvesting? 0.00×HarvestingCapex $0 ÷ depreciation $53K
What this means
Descriptive, not a grade. Above ~1× means investing faster than assets wear out (growth, or, sustained for years, today's earnings carrying less depreciation than tomorrow's will). Below means spending less than it's wearing out (efficiency, or a melting asset base). The ratio won't tell you which; the filings will.
Graham’s defensive tests · 2 of 5 met
Graham’s numerical criteria for the defensive investor (The Intelligent Investor, ch. 14), run on the filings. A floor of safety, not a buy signal; many fine modern businesses fail his strictest liquidity rules by design.
- Adequate size MissRevenue ≥ $2B · $14M
What this means
Big enough to weather a storm. Graham's 1972 floor was ~$100M of sales (≈ $700M today); we use a $2B revenue line as a conservative modern stand-in.
- Strong liquidity PassCurrent ratio ≥ 2× · 6.43×
What this means
Current assets at least twice current liabilities, near-term bills covered without touching the business. Strict by design: many cash-rich modern firms run leaner and miss it, holding their cushion in longer-dated securities.
- Conservative debt PassDebt ≤ working capital · $1M vs $42M WC
What this means
Graham's rule that borrowings not exceed net current assets. Capital-heavy and buyback-heavy firms routinely fail it, read it next to interest coverage, not alone.
- Earnings stability MissA profit every year (10-yr record) · 9 loss years
What this means
Graham wanted earnings in each of the past ten years, the stability a defensive owner leans on.
- Dividend record MissUninterrupted dividends · none paid
What this means
An unbroken dividend was Graham's mark of durability. He wanted twenty years; the filings show about ten, and a single suspension breaks the streak. Non-payers, many fine modern compounders, fall outside his defensive net by design.
- Earnings growth —Earnings +33% over the record · —
What this means
Earnings were negative early in the record, a growth rate isn't meaningful.
- Moderate price —P/E ≤ 15 and P/E × P/B ≤ 22.5 · decided by the price
What this means
Graham's valuation gate, the wall he kept between a sound business and a sound investment. Three-year average earnings are $-0.48/share (latest year $-0.61), the averaged base the calculator's gate runs on, and book value is $0.19/share. Enter a price in “What the price implies” just below for the P/E, P/B, and whether it clears. But this is the rule Buffett outgrew: there's no hard P/E law, and a wonderful business can deserve a far richer multiple if the thesis holds, treat it as the bargain-hunter's floor, not a verdict on the price.
Durability & moat, 2011–2025
Whether the record’s returns held, and what the capital reinvested earned.
- Profitable years 1 of 10
What this means
Lost money in 9 year(s), look at what happened there before trusting the average.
- Operating margin −1316% → −297% (3-yr avg ends)
In the filing’s words The record and the words agree: the margin widened and the filing attributes the gain to its own pricing, not volume alone.
What this means
Through the cycle the operating margin widened — about −1316% early to −297% lately, median −272% — pricing power intact or improving.
- Worst year 2021 · −3854.8% op. margin
What this means
Operations went underwater in 2021, understand why before trusting the good years.
- Share count −2.8%/yr
What this means
The share count is shrinking, buybacks are quietly growing your slice of the business.
Does AI threaten the moat?
Low contestabilityThe moat is physical, regulated or balance-sheet-funded, the kind AI cuts costs within but does not contest.
Its FY2025 10-K names artificial intelligence as a competitive threat.
“Our competitors may also render our technologies obsolete by advances in existing technological approaches or the development of new or different approaches, such as using artificial intelligence and machine learning, potentially eliminating the advantages in our drug discovery process.…”
AI is unlikely to contest a moat that is physical, regulated or balance-sheet-funded; here it reads more as a cost tool than a threat.
Read from the filing's own risk factors, paired with the industry's structure under its SIC code; the durability is read above, the price below.
All figures as filed; the source filing is linked above.
Current Position
as of the latest quarter, Mar 31, 2026Can the business pay what it owes this year, off the freshest balance sheet: the quality of the assets, the debt actually coming due, and what a low ratio means here.
- Cash & short-term investments$60M
- Receivables$2M
- Other current assets$5M
- Accounts payable$4M
- Other current liabilities$5M
From the company's latest filing.
Management, ownership & pay
read the proxy →From the proxy: how much of the business the people running it own, and how they are paid.
- Insider ownership<1%
The stake all directors and executive officers hold together, per the 2026 proxy: skin in the game, the first thing Munger reads.
- Stock-based compensation$3M
The slice of the business handed to employees in shares this year, 24% of revenue. Buffett's oldest accounting fight: this is compensation, compensation is an expense, real whether or not the headline earnings admit it. One trap: the cash-flow statement adds SBC back, so the operating cash, and the owner earnings drawn from it, are flattered by exactly this amount; counted as the cost it is, what an owner keeps is lower.
Peers, Pharmaceuticals
The same industry, side by side on owner economics. Each figure is a through-cycle median, so a peak or trough year can’t distort it; the group median at the foot is the line to read each against.
| Company | Revenue | Gross margin | Op. margin | ROIC | Owner earn. margin |
|---|---|---|---|---|---|
| QUREuniQure N.V. | $16M | 94% | -611.9% | -87% | -605% |
| IRDOpus Genetics Inc. | $14M | 99% | -205.8% | — | -248% |
| ABUSArbutus Biopharma Corporation | $14M | — | -936.4% | -85% | -685% |
| EVMNEvommune Inc. | $13M | — | -623.6% | -40% | -590% |
| PRLDPrelude Therapeutics Incorporated | $12M | — | -861.3% | -247% | -464% |
| XOMAXOMA Royalty Corporation | $10M | — | -177.6% | -16% | -250% |
| ZBIOZenas BioPharma Inc. | $10M | — | -3277.8% | -144% | -1724% |
| PRTAProthena Corporation plc | $10M | — | -1390.3% | — | -1090% |
| Group median | — | — | -742.5% | — | -598% |
The price
What a price has to assume.
What the price implies
reverse-DCFOpus Genetics Inc. is profitable, but owner earnings are negative this year because capital spending currently outruns operating cash, a build-out, so the owner-earnings reverse-DCF has no positive base to grow. We read the price from both ends instead: type a price to see the steady-state profitability it demands, then set the mature margin you would believe and weigh the two against each other. Nothing leaves your browser unless you enter it in your notebook.
Revenue, delivered−31%/yr’20→’25
Enter a price to run it.
A dated snapshot of the price you typed, the assumptions you set, and what the page showed for them. A snapshot is never edited after it is saved. Your notebook is yours alone — the commitment states what is stored and what we will never do.
Two reads of one future. From your price: the owner earnings the company must reach, valued at a mature multiple and discounted back at your rate, expressed as the margin it implies on revenue grown at your rate. From your belief: the mature margin you would credit, set on the dial above. When the margin the price demands runs above the one you would believe, you are paying for a future taken on faith. For a deep cyclical at a trough, normalized through-cycle earnings are the better lens; this mode is for the genuinely unprofitable, and for the profitable business whose capital spending currently outruns its cash.
Manual order: ← IR its page in the Manual IRDM →
Industry order: ← IONS the Pharmaceuticals chapter IRWD →