Share count
138Mpeak FY2025
← All companies ← CTKB Manual CTO → ← CRON Pharmaceuticals CYRX →
CTMX, CytomX Therapeutics Inc.
We are a clinical-stage, oncology-focused biopharmaceutical company dedicated to developing innovative therapies to address major unmet need in oncology.
CytomX has led the field of conditionally activated, masked biologics through the development of its PROBODY technology platform.
CytomX's experience and leadership with the PROBODY platform for over 15 years has led to a highly focused strategy for the application of its technology in product development that has resulted in a current pipeline of novel clinical-stage and pre-clinical stage programs.
The business
What it sells, where the money comes from, the kind of company it is.
Revenue · FY2025
$76M
−44.8% YoY · 2% 5-yr CAGR
Vital signs · TTM
Cash & investments $236M
Cash burn · annual $80M
Runway 2.9 yrs
The business in brief
read the 10-K →What this business is and what moves its needle, from its own SEC filings.
- Situation
- Unprofitable. No sustained operating profit across the record; an earnings multiple has nothing to rest on. What the record does show is revenue, the gross-margin trajectory, and the burn against the cash on hand. Net current asset value. Current assets alone exceed every liability combined, and the surplus is most of the balance sheet: the shape Graham called a net-net.
- What moves the needle
- Operating margin has reached 18% at its best but run negative through the cycle (median −131%) — so the question is which reading is truer: whether the median was pulled below zero by one-off charges, by the cycle, or by spending it is still growing into, and whether it settles back at a profit. Stock-based pay runs about 22% of sales, a real and recurring claim on owners that the GAAP margin understates. Read this kind of business on the pipeline against the patent cliff, and pricing. On its own account, the filing leans hardest on pricing power & competition, set against the numbers in what the filing emphasizes, below.
Every line is arithmetic on the company's filings, shown in full in the sections below.
The record
Ten years of arithmetic, read across the cycle.
The record, 2016–2025
realized figures from each filing · older years to the left| 2016’16 | 2017’17 | 2018’18 | 2019’19 | 2020’20 | 2021’21 | 2022’22 | 2023’23 | 2024’24 | 2025’25 | TTMTTMMar 2026 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Income statement | |||||||||||
| $13M | $72M | $60M | $27M | $68M | $37M | $53M | $101M | $138M | $76M | $36M | RevenueRevenue |
| 155% | 36% | 56% | 137% | 53% | 105% | 81% | 30% | 22% | 39% | 88% | SG&A / revenueSG&A/rev |
| 426% | 129% | 175% | 489% | 165% | 306% | 210% | 77% | 60% | 90% | 194% | R&D / revenueR&D/rev |
| ($60M) | ($46M) | ($78M) | ($141M) | ($81M) | ($116M) | ($101M) | ($6M) | $25M | ($22M) | ($65M) | Operating incomeOp. inc. |
| −463.9% | −64.6% | −130.9% | −525.9% | −117.7% | −311.0% | −190.6% | −6.4% | 18.1% | −29.3% | −181.9% | Operating marginOp. mgn |
| ($59M) | ($43M) | ($85M) | ($133M) | ($65M) | ($116M) | ($99M) | ($569K) | $32M | ($17M) | ($59M) | Net incomeNet inc. |
| Cash flow & returns | |||||||||||
| ($2M) | $170M | ($76M) | ($140M) | $5M | ($119M) | ($111M) | ($56M) | ($86M) | ($76M) | ($80M) | Operating cash flowOp. cash |
| $2M | $2M | $2M | $3M | $2M | $3M | $2M | $2M | $2M | $1M | $1M | DepreciationDeprec. |
| $45M | $201M | ($10M) | ($29M) | $53M | ($19M) | ($27M) | ($66M) | ($127M) | ($66M) | ($31M) | Working capital & otherWC & other |
| $2M | $2M | $4M | $3M | $2M | $2M | $2M | $840K | $310K | $220K | $101K | CapexCapex |
| 16.9% | 2.2% | 6.4% | 13.0% | 3.4% | 4.3% | 3.3% | 0.8% | 0.2% | 0.3% | 0.3% | Capex / revenueCapex/rev |
| ($4M) | $169M | ($77M) | ($143M) | $3M | ($121M) | ($113M) | ($57M) | ($87M) | ($76M) | ($80M) | Owner earningsOwner earn. |
| −29.3% | 235.7% | −130.1% | −531.5% | 4.3% | −323.3% | −211.7% | −56.2% | −62.7% | −99.5% | −225.6% | Owner earnings marginOE mgn |
| ($4M) | $169M | ($79M) | ($144M) | $3M | ($121M) | ($113M) | ($57M) | ($87M) | ($76M) | ($80M) | Free cash flowFCF |
| −32.8% | 235.7% | −133.3% | −535.2% | 4.3% | −323.3% | −211.7% | −56.2% | −62.7% | −99.5% | −225.6% | Free cash flow marginFCF mgn |
| -75% | -62% | -62% | -521% | — | — | — | — | — | -18% | -18% | Return on equityROE |
| −75% | −62% | −62% | −521% | — | — | — | — | — | −18% | −18% | Retained to equityRetained/eq |
| Balance sheet | |||||||||||
| $182M | $374M | $248M | $188M | $192M | $206M | $194M | $17M | $38M | $13M | $236M | Cash & investmentsCash+inv |
| $2M | $10M | $97K | $13K | $798K | $790K | $36M | $3M | $3M | $2M | $646K | ReceivablesReceiv. |
| $7M | $4M | $5M | $4M | $3M | $3M | $3M | $1M | $1M | $1M | $1M | Accounts payablePayables |
| ($4M) | $6M | ($5M) | ($4M) | ($2M) | ($2M) | $33M | $2M | $2M | $712K | ($722K) | Operating working capitalOper. WC |
| $188M | $389M | $445M | $303M | $324M | $310M | $237M | $183M | $107M | $144M | $353M | Current assetsCur. assets |
| $36M | $61M | $98M | $86M | $68M | $65M | $153M | $156M | $86M | $47M | $34M | Current liabilitiesCur. liab. |
| 5.3× | 6.4× | 4.5× | 3.5× | 4.8× | 4.8× | 1.6× | 1.2× | 1.3× | 3.1× | 10.4× | Current ratioCurr. ratio |
| $949K | $949K | $949K | $949K | $949K | $949K | $949K | $949K | $949K | $949K | $949K | GoodwillGoodwill |
| $199M | $398M | $457M | $341M | $359M | $339M | $261M | $202M | $121M | $152M | $359M | Total assetsAssets |
| $78M | $70M | $136M | $25M | ($8M) | ($459K) | ($86M) | ($47M) | ($456K) | $99M | $320M | Shareholders’ equityEquity |
| 78.6% | 15.8% | 28.4% | 71.0% | 21.6% | 35.3% | 24.7% | 8.5% | 5.6% | 8.3% | 25.3% | Stock comp / revenueSBC/rev |
| Per share | |||||||||||
| 36.2M | 37.2M | 41.7M | 45.3M | 46.1M | 64.1M | 65.7M | 73.8M | 84.7M | 138M | 177M | Shares out (diluted)Shares |
| $0.35 | $1.93 | $1.43 | $0.59 | $1.48 | $0.58 | $0.81 | $1.37 | $1.63 | $0.55 | $0.20 | Revenue / shareRev/sh |
| $-1.63 | $-1.16 | $-2.03 | $-2.93 | $-1.40 | $-1.81 | $-1.51 | $-0.01 | $0.38 | $-0.13 | $-0.33 | EPS (diluted)EPS |
| $-0.10 | $4.54 | $-1.86 | $-3.15 | $0.06 | $-1.88 | $-1.71 | $-0.77 | $-1.02 | $-0.55 | $-0.45 | Owner earnings / shareOE/sh |
| $-0.12 | $4.54 | $-1.90 | $-3.18 | $0.06 | $-1.88 | $-1.71 | $-0.77 | $-1.02 | $-0.55 | $-0.45 | Free cash flow / shareFCF/sh |
| $0.06 | $0.04 | $0.09 | $0.08 | $0.05 | $0.03 | $0.03 | $0.01 | $0.00 | $0.00 | $0.00 | Cap. spending / shareCapex/sh |
| $2.17 | $1.88 | $3.26 | $0.56 | $-0.17 | $-0.01 | $-1.30 | $-0.64 | $-0.01 | $0.72 | $1.80 | Book value / shareBVPS |
The diluted share count moved ×1.63 into 2025 — shares issued, not a split the totals corroborate — and the per-share figures carry the counts as filed.
Per-share growththe realized rate an owner's share compounded
| 9-yr | 5-yr | |
|---|---|---|
| Revenue / share | +5.1%/yr | −17.9%/yr |
| Capital spending / share | −33.2%/yr | −49.8%/yr |
| Book value / share | −11.5%/yr | — |
The record, charted
FY2016–2025Each measure over its full record; the current point and the worst year marked.
Owner earnings vs. net income
Owner earningsNet incomeThe accountant's number, and the cash an owner can take; the gap is the tell.
($76M)owner earningsvs.($17M)net incomelow FY2019
Net income is the accountant's number; owner earnings is the cash an owner could take out. The walk between them, off the cash-flow statement, and whether the gap is widening or holding.
In fiscal 2025 the business reported a $17M loss but ($76M) of owner earnings: $58M less than the profit line, taken out by capital spending and the timing of cash.
| FY2025 | FY2024 | FY2023 | FY2022 | FY2021 | |
|---|---|---|---|---|---|
| Reported net income | ($17M) | $32M | ($569K) | ($99M) | ($116M) |
| Depreciation & amortizationnon-cash charge added back | +$1M | +$2M | +$2M | +$2M | +$3M |
| Stock-based compensationreal costnon-cash, but a real cost | +$6M | +$8M | +$9M | +$13M | +$13M |
| Working capital & othertiming of cash in and out, other non-cash items | −$66M | −$127M | −$66M | −$27M | −$19M |
| Cash from operations | ($76M) | ($86M) | ($56M) | ($111M) | ($119M) |
| Capital expenditurecash put back in to keep running and to grow | −$220K | −$310K | −$840K | −$2M | −$2M |
| Owner earnings | ($76M) | ($87M) | ($57M) | ($113M) | ($121M) |
| Owner-earnings marginowner earnings ÷ revenue | -99% | -63% | -56% | -212% | -323% |
Owner earnings is the cash an owner could pull out without starving the business: operating cash less the capital it must spend to hold its position . The cash-flow statement also adds stock comp back as non-cash, but it is a real cost paid in shares; counted as the expense it is (less $6M), owner earnings is nearer ($82M).
Maintenance capex is estimated as depreciation where a growing business invests above it; free cash flow is the figure the scorecard's free-cash margin reads.
Quality & stewardship
Returns, the balance sheet, capital allocation, and pay.
Owner’s Scorecard
FY2025 10-K · source on SEC EDGAR →
Material weakness in financial controls
“In connection with preparing our financial statements for the year ending December 31, 2022, we determined that a material weakness existed in our internal control over financial reporting due to ineffective controls for evaluation and review of the…”
The figures below are only as sound as the controls that produced them. read the note →
Will it survive?
- Can it pay its interest? -13.2×Does not cover its interestOperating income ($22M) ÷ interest expense $2M
What this means
A full year of operating profit didn't cover the interest bill. This is the zombie zone: the business depends on refinancing, asset sales, or forbearance to service its debt.
- Net cashCash $13M + ST investments $197M − debt $3M
What this means
Cash and short-term investments exceed every dollar of debt by $206M, on net the company owes nothing, and can act from strength when others can't. Net debt is the leverage figure that matters: the cash is already set against the debt. Strategic or illiquid investments aren't counted here.
- Not enough data
What this means
The filing data didn't include the inputs for this check.
Is it a good business?
- Below averageNOPAT ($18M) ÷ invested capital $89M (debt + equity − cash)Industry peers: median -108%
What this means
The rate the business earns on the money tied up in it, Buffett's north star, because over time a stock tracks the ROIC beneath it. Above ~15% sustained hints at a moat; a return below the cost of capital (~8%) erodes value as a business grows rather than building it — the test Buffett weighs most. Asset-light businesses (R&D expensed, little capital) read artificially high, pair this with Owner Earnings.
- Consumes cash through the cycle10-yr median margin, range -531%–236%; latest ($76M) = operating cash ($76M) − maintenance capex $220KIndustry peers: median -176%
What this means
What an owner could take out without starving the business: operating cash less the maintenance capital it must spend to hold its position — Buffett's owner earnings. That's -99% of revenue this year, a -99% median across 10 years. Treating stock comp as the real expense it is (less $6M of SBC) leaves ($82M).
- Are earnings backed by cash? ($76M)Loss, and burning cashNet income ($17M) · cash from operations ($76M)
In the filing’s words The filing discloses a material weakness in its financial controls — the reported numbers here, and the record built on them, are only as reliable as the controls that produced them.
What this means
The company reported a net loss, so a conversion ratio isn't meaningful. What matters then is whether operations still threw off cash, here, they did not.
How is the cash used?
- Not enough data
What this means
The filing data didn't include the inputs for this check.
- Investing or harvesting? 0.18×HarvestingCapex $220K ÷ depreciation $1M
What this means
Descriptive, not a grade. Above ~1× means investing faster than assets wear out (growth, or, sustained for years, today's earnings carrying less depreciation than tomorrow's will). Below means spending less than it's wearing out (efficiency, or a melting asset base). The ratio won't tell you which; the filings will.
Graham’s defensive tests · 2 of 5 met
Graham’s numerical criteria for the defensive investor (The Intelligent Investor, ch. 14), run on the filings. A floor of safety, not a buy signal; many fine modern businesses fail his strictest liquidity rules by design.
- Adequate size MissRevenue ≥ $2B · $76M
What this means
Big enough to weather a storm. Graham's 1972 floor was ~$100M of sales (≈ $700M today); we use a $2B revenue line as a conservative modern stand-in.
- Strong liquidity PassCurrent ratio ≥ 2× · 3.09×
What this means
Current assets at least twice current liabilities, near-term bills covered without touching the business. Strict by design: many cash-rich modern firms run leaner and miss it, holding their cushion in longer-dated securities.
- Conservative debt PassDebt ≤ working capital · $3M vs $97M WC
What this means
Graham's rule that borrowings not exceed net current assets. Capital-heavy and buyback-heavy firms routinely fail it, read it next to interest coverage, not alone.
- Earnings stability MissA profit every year (10-yr record) · 9 loss years
What this means
Graham wanted earnings in each of the past ten years, the stability a defensive owner leans on.
- Dividend record MissUninterrupted dividends · none paid
What this means
An unbroken dividend was Graham's mark of durability. He wanted twenty years; the filings show about ten, and a single suspension breaks the streak. Non-payers, many fine modern compounders, fall outside his defensive net by design.
- Earnings growth —Earnings +33% over the record · —
What this means
Earnings were negative early in the record, a growth rate isn't meaningful.
- Moderate price —P/E ≤ 15 and P/E × P/B ≤ 22.5 · decided by the price
What this means
Graham's valuation gate, the wall he kept between a sound business and a sound investment. Three-year average earnings are $0.02/share (latest year $-0.08), the averaged base the calculator's gate runs on, and book value is $0.45/share. Enter a price in “What the price implies” just below for the P/E, P/B, and whether it clears. But this is the rule Buffett outgrew: there's no hard P/E law, and a wonderful business can deserve a far richer multiple if the thesis holds, treat it as the bargain-hunter's floor, not a verdict on the price.
Durability & moat, 2016–2025
Whether the record’s returns held, and what the capital reinvested earned.
- Profitable years 1 of 10
What this means
Lost money in 9 year(s), look at what happened there before trusting the average.
- Operating margin −220% → −6% (3-yr avg ends)
In the filing’s words The margin widened even though the filing names price competition — the gain came from volume or cost, not pricing power. Read where.
What this means
Through the cycle the operating margin widened — about −220% early to −6% lately, median −131% — pricing power intact or improving.
- Worst year 2019 · −525.9% op. margin
What this means
Operations went underwater in 2019, understand why before trusting the good years.
Does AI threaten the moat?
Low contestabilityThe moat is physical, regulated or balance-sheet-funded, the kind AI cuts costs within but does not contest.
In its own filing A competitive risk, new this year
Its FY2025 10-K names artificial intelligence as a competitive threat, in language that was not in the prior year's filing.
“It is possible that new laws and regulations will be adopted in the United States and in other non-U.S. jurisdictions, or that existing laws and regulations, including competition and antitrust laws, may be interpreted in ways that would limit our ability to use AI Technologies for our business, or require us to change…”
AI is unlikely to contest a moat that is physical, regulated or balance-sheet-funded; here it reads more as a cost tool than a threat.
Read from the filing's own risk factors, paired with the industry's structure under its SIC code; the durability is read above, the price below.
All figures as filed; the source filing is linked above.
Current Position
as of the latest quarter, Mar 31, 2026Can the business pay what it owes this year, off the freshest balance sheet: the quality of the assets, the debt actually coming due, and what a low ratio means here.
Current assets$353M
- Cash & short-term investments$234M
- Receivables$646K
- Other current assets$119M
Current liabilities$34M
- Debt due within a year$1M
- Accounts payable$1M
- Other current liabilities$31M
Current ratio10.38×all current assets ÷ what's due · Graham looked for 2×
Quick ratio—inventory untagged this quarter, so withheld rather than shown equal to the current ratio
Cash ratio6.87×strictest: cash alone against what's due
Working capital$319Mthe cushion left after near-term bills
Debt due this year vs. cash$1M due · $234M cash
covered by cash on hand, no refinancing forced · both figures from the Mar 31, 2026 balance sheet
Cash runway2.9 yrsthe business is consuming cash; this is how long the cash on hand lasts at that rate
Revenue, latest quarter vs. a year ago−79.9%the freshest read on whether the business is still growing
Current ratio, recent quarters1.0× → 10.4×
Deeper floors
Tangible book value$317Mequity stripped of goodwill & intangibles
Net current asset value$314MGraham's net-net: current assets less all liabilities
Debt incl. operating leases$6M$3M of it operating leases
Deferred revenue$19Mcustomer cash collected before delivery; operating float
From the company's latest filing.
Management, ownership & pay
read the proxy →From the proxy: how much of the business the people running it own, and how they are paid, beside what the business earned for its owners in the same years.
| Fiscal year | Chief executive | Pay, as filed | “Actually paid” | Owner earnings |
|---|---|---|---|---|
| 2023 | Sean A. McCarthy, D. Phil. | $2.6M | $519k | ($57M) |
| 2024 | Sean A. McCarthy, D. Phil. | $1.8M | $1.1M | ($87M) |
| 2025 | Sean A. McCarthy, D. Phil. | $4.7M | $10.6M | ($76M) |
Both pay figures are the company’s own, from the pay-versus-performance table its proxy statement files. “As filed” is the Summary Compensation Table total: salary, bonus, and equity awards at their value on the day of grant. “Actually paid” is the SEC’s prescribed recalculation, which re-marks those equity awards to what they became as they vested; it can swing far above or below the filed figure in either direction, and negative years occur. Owner earnings are the whole business's, from the record above, for the same fiscal years.
- Insider ownership3.8%
The stake all directors and executive officers hold together, per the 2026 proxy: skin in the game, the first thing Munger reads.
- Stock-based compensation$6M
The slice of the business handed to employees in shares this year, 8% of revenue. Buffett's oldest accounting fight: this is compensation, compensation is an expense, real whether or not the headline earnings admit it. One trap: the cash-flow statement adds SBC back, so the operating cash, and the owner earnings drawn from it, are flattered by exactly this amount; counted as the cost it is, what an owner keeps is lower.
Inverting the record
Invert: instead of why CytomX Therapeutics Inc. is a good business, the question is what would make owning it a mistake, and whether those marks are in the record. Disconfirming tests across 2016–2025.
1 of the 3 tests turned up something to look into; the other 2 came back clean.
- Look hereIs it less profitable than it was?−72.8% vs −51.7%
The business ran at a loss early in the record (an owner-earnings margin of −51.7%) and the loss has widened to −72.8% across the last three years, with the latest year at −99.5%. Ask the filing where the widening sits — price, cost, or spending growing faster than revenue — and what would narrow it.
And these came back clean
- Did receivables and inventory outpace sales?
- Are "one-time" charges a yearly habit?
Each test is read from the filings and is noisy alone; a flag can mark a cyclical trough or a year of heavy investment as easily as a problem. The filing says which.
Peers, Pharmaceuticals
The same industry, side by side on owner economics. Each figure is a through-cycle median, so a peak or trough year can’t distort it; the group median at the foot is the line to read each against.
| Company | Revenue | Gross margin | Op. margin | ROIC | Owner earn. margin |
|---|---|---|---|---|---|
| ARCTArcturus Therapeutics Holdings Inc. | $82M | — | -107.8% | -71% | -65% |
| ADCTADC Therapeutics SA | $81M | 93% | -174.6% | — | -176% |
| ETONEton Pharmaceuticals Inc. | $80M | 60% | -6.8% | -108% | 2% |
| CTMXCytomX Therapeutics Inc. | $76M | — | -124.3% | -20% | -81% |
| OMEROmeros Corporation | $74M | 98% | -451.5% | -213% | -417% |
| BCYCBicycle Therapeutics plc | $73M | — | -561.0% | -1553% | -236% |
| ASMBAssembly Biosciences Inc. | $72M | — | -602.7% | -70% | -130% |
| VRDNViridian Therapeutics Inc. | $71M | 96% | -1815.9% | — | -1328% |
| Group median | — | — | -313.0% | -90% | -153% |
The price
What a price has to assume.
What the price implies
reverse-DCFCytomX Therapeutics Inc. is profitable, but owner earnings are negative this year because capital spending currently outruns operating cash, a build-out, so the owner-earnings reverse-DCF has no positive base to grow. We read the price from both ends instead: type a price to see the steady-state profitability it demands, then set the mature margin you would believe and weigh the two against each other. Nothing leaves your browser unless you enter it in your notebook.
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The assumptions
Revenue, delivered16%/yr’20→’25
Enter a price to run it.
Owner earnings it must reach—
Margin the price demands—
Owner-earnings margin today−226%
A dated snapshot of the price you typed, the assumptions you set, and what the page showed for them. A snapshot is never edited after it is saved. Your notebook is yours alone — the commitment states what is stored and what we will never do.
Two reads of one future. From your price: the owner earnings the company must reach, valued at a mature multiple and discounted back at your rate, expressed as the margin it implies on revenue grown at your rate. From your belief: the mature margin you would credit, set on the dial above. When the margin the price demands runs above the one you would believe, you are paying for a future taken on faith. For a deep cyclical at a trough, normalized through-cycle earnings are the better lens; this mode is for the genuinely unprofitable, and for the profitable business whose capital spending currently outruns its cash.
Cite: Owner Scorecard, "CytomX Therapeutics Inc. (CTMX), the owner's record," https://ownerscorecard.com/c/CTMX, data as of 2026-07-09.
Manual order: ← CTKB its page in the Manual CTO →
Industry order: ← CRON the Pharmaceuticals chapter CYRX →