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XERS, Xeris Biopharma Holdings Inc.
We are a commercial-stage biopharmaceutical company focused on developing and commercializing therapies for people with chronic endocrine and neurological diseases in the United States.
We are advancing our Phase 3-ready pipeline product, XP-8121, once-weekly subcutaneous ("SC") levothyroxine, which leverages our proprietary technology XeriSol.
Our top priority is maximizing the potential of our three commercial products: Recorlev is a cortisol synthesis inhibitor approved for the treatment of endogenous hypercortisolemia in adults with Cushing's syndrome for whom surgery is not an option or has not been curative.
The business
What it sells, where the money comes from, the kind of company it is.
The business in brief
read the 10-K →What this business is and what moves its needle, from its own SEC filings.
- What it is
- Revenue is led by Recorlev (48%) and Gvoke (32%), with 2 more lines behind.
- Situation
- Distress / turnaround. Thin interest coverage, or operating cash burned against real debt, across the record. The balance sheet carries this situation; the debt schedule sets the clock.
- What moves the needle
- Operating margin has run around −74% through the cycle, the operating line deeply negative — so the lever is the path to a margin at all: revenue growth against the cost curve and the cash runway, not the level of a margin that isn't there yet. Inventory runs near 24% of sales, so how fast it turns back into cash — and the risk of writing it down when demand softens — sits alongside the margin. Read this kind of business on the pipeline against the patent cliff, and pricing. On its own account, the filing leans hardest on customer concentration, set against the numbers in what the filing emphasizes, below.
- Is it a good business?
- Return on capital has rarely cleared the cost of capital (median −44%, above 15% in 1 of 6 years). Owner earnings, the cash-based check, have been thin too. This is price-taker territory, where the balance sheet and the cycle matter more than any multiple; the rest is in the 10-K.
Every line is arithmetic on the company's filings, shown in full in the sections below.
Where the money comes from
read the 10-K →Revenue spreads across 5 lines, the largest Recorlev at 48%.
- Recorlev48%$139M
- Gvoke32%$94M
- Keveyis16%$48M
- Royalty, contract and other revenue3%$9M
- Product, Other1%$2M
From the segment footnote of the company's own 10-K. Shares are of total revenue; the profit bar shows each segment's share of segment operating profit, before unallocated corporate costs.
The record
Ten years of arithmetic, read across the cycle.
The record, 2020–2025
realized figures from each filing · older years to the left| 2020’20 | 2021’21 | 2022’22 | 2023’23 | 2024’24 | 2025’25 | TTMTTMMar 2026 | |
|---|---|---|---|---|---|---|---|
| Income statement | |||||||
| $20M | $50M | $110M | $164M | $203M | $292M | $315M | RevenueRevenue |
| 366% | 254% | 125% | 89% | 81% | 62% | 61% | SG&A / revenueSG&A/rev |
| 104% | 51% | 19% | 14% | 13% | 11% | 10% | R&D / revenueR&D/rev |
| ($84M) | ($115M) | ($82M) | ($44M) | ($34M) | $25M | $36M | Operating incomeOp. inc. |
| −414.5% | −232.2% | −74.3% | −26.8% | −16.6% | 8.5% | 11.4% | Operating marginOp. mgn |
| ($91M) | ($123M) | ($95M) | ($62M) | ($55M) | $554K | $12M | Net incomeNet inc. |
| Cash flow & returns | |||||||
| ($81M) | ($96M) | ($103M) | ($47M) | ($37M) | $29M | $49M | Operating cash flowOp. cash |
| $1M | $1M | $1M | $1M | $1M | $1M | $1M | DepreciationDeprec. |
| $842K | $14M | ($22M) | $3M | ($2M) | $4M | $13M | Working capital & otherWC & other |
| $377K | $1M | — | — | — | — | $1M | CapexCapex |
| 1.9% | 2.2% | — | — | — | — | 0.3% | Capex / revenueCapex/rev |
| ($81M) | ($97M) | — | — | — | — | $47M | Owner earningsOwner earn. |
| −401.6% | −194.8% | — | — | — | — | 15.1% | Owner earnings marginOE mgn |
| ($81M) | ($97M) | — | — | — | — | $47M | Free cash flowFCF |
| −401.6% | −194.8% | — | — | — | — | 15.1% | Free cash flow marginFCF mgn |
| -79% | -78% | -59% | -30% | -20% | 20% | 29% | ROICROIC |
| -270% | -129% | -209% | — | — | 4% | 92% | Return on equityROE |
| −270% | −129% | −209% | — | — | 4% | 92% | Retained to equityRetained/eq |
| Balance sheet | |||||||
| $134M | $102M | $122M | $72M | $72M | $111M | $112M | Cash & investmentsCash+inv |
| $7M | $17M | $31M | $39M | $40M | $51M | $56M | ReceivablesReceiv. |
| $8M | $18M | $25M | $39M | $48M | $69M | $74M | InventoryInvent. |
| $3M | $9M | $5M | $12M | $2M | $3M | $11M | Accounts payablePayables |
| $12M | $27M | $51M | $66M | $86M | $117M | $119M | Operating working capitalOper. WC |
| $152M | $143M | $187M | $156M | $168M | $240M | $252M | Current assetsCur. assets |
| $28M | $79M | $74M | $95M | $100M | $110M | $119M | Current liabilitiesCur. liab. |
| 5.4× | 1.8× | 2.5× | 1.6× | 1.7× | 2.2× | 2.1× | Current ratioCurr. ratio |
| $0 | $23M | $23M | $23M | $23M | $23M | $23M | GoodwillGoodwill |
| $159M | $304M | $345M | $323M | $323M | $384M | $392M | Total assetsAssets |
| $87M | $88M | $187M | $191M | $232M | $220M | $221M | Total debtDebt |
| ($47M) | ($14M) | $65M | $118M | $160M | $109M | $109M | Net debt / (cash)Net debt |
| -7.8× | -16.0× | -5.8× | -1.7× | -1.1× | 0.9× | 1.3× | Interest coverageInt. cov. |
| $34M | $95M | $45M | ($7M) | ($30M) | $14M | $13M | Shareholders’ equityEquity |
| 41.0% | 23.0% | 11.0% | 6.5% | 9.0% | 7.7% | 7.0% | Stock comp / revenueSBC/rev |
| Per share | |||||||
| 42.6M | 79.0M | 136M | 138M | 147M | 173M | 178M | Shares out (diluted)Shares |
| $0.47 | $0.63 | $0.81 | $1.19 | $1.38 | $1.69 | $1.77 | Revenue / shareRev/sh |
| $-2.14 | $-1.55 | $-0.70 | $-0.45 | $-0.37 | $0.00 | $0.07 | EPS (diluted)EPS |
| $-1.90 | $-1.22 | — | — | — | — | $0.27 | Owner earnings / shareOE/sh |
| $-1.90 | $-1.22 | — | — | — | — | $0.27 | Free cash flow / shareFCF/sh |
| $0.01 | $0.01 | — | — | — | — | $0.01 | Cap. spending / shareCapex/sh |
| $0.79 | $1.21 | $0.33 | $-0.05 | $-0.20 | $0.08 | $0.07 | Book value / shareBVPS |
The diluted share count moved ×1.85 into 2021 — shares issued, not a split the totals corroborate — and the per-share figures carry the counts as filed.
The diluted share count moved ×1.72 into 2022 — shares issued, not a split the totals corroborate — and the per-share figures carry the counts as filed.
| 5-yr | 5-yr | |
|---|---|---|
| Revenue / share | +29.0%/yr | +29.0%/yr |
| Capital spending / share | +55.3%/yr (1-yr) | +55.3%/yr (1-yr) |
| Book value / share | −36.9%/yr | −36.9%/yr |
The year, in the company's words
the filing →Verbatim from the 10-K's management discussion. Each sentence is shown only because its subject, direction, and stated figures check out against the filed numbers on this page. The words are the company's; the arithmetic is the record's.
- Gvoke+13.6%
“Gvoke Net revenue increased by $11.3 million or 13.6% for the year ended December 31, 2025 compared to the year ended December 31, 2024. The increase was due to favorable net pricing ($8.6 million or 10.4%) and higher volume ($2.7 million or 3.2%).”
✓ figure matches the filed record - Keveyis-3.8%
“Keveyis Net revenue decreased by $1.9 million or 3.8% for the year ended December 31, 2025 compared to the year ended December 31, 2024. The decrease was due to unfavorable net pricing ($5.0 million or 10.1%), offset by higher volume ($3.1 million or 6.3%).”
✓ figure matches the filed record
The record, charted
FY2020–2025Each measure over its full record; the current point and the worst year marked.
Net income is the accountant's number; owner earnings is the cash an owner could take out. The walk between them, off the cash-flow statement, and whether the gap is widening or holding.
In fiscal 2021 the business turned a $123M loss into ($97M) of owner earnings: more cash than the profit line showed, after the non-cash charges and the capital it put back in.
| FY2021 | FY2020 | |
|---|---|---|
| Reported net income | ($123M) | ($91M) |
| Depreciation & amortizationnon-cash charge added back | +$1M | +$1M |
| Stock-based compensationreal costnon-cash, but a real cost | +$11M | +$8M |
| Working capital & othertiming of cash in and out, other non-cash items | +$14M | +$842K |
| Cash from operations | ($96M) | ($81M) |
| Capital expenditurecash put back in to keep running and to grow | −$1M | −$377K |
| Owner earnings | ($97M) | ($81M) |
| Owner-earnings marginowner earnings ÷ revenue | -195% | -402% |
Owner earnings is the cash an owner could pull out without starving the business: operating cash less the capital it must spend to hold its position . The cash-flow statement also adds stock comp back as non-cash, but it is a real cost paid in shares; counted as the expense it is (less $11M), owner earnings is nearer ($108M).
Maintenance capex is estimated as depreciation where a growing business invests above it; free cash flow is the figure the scorecard's free-cash margin reads.
Quality & stewardship
Returns, the balance sheet, capital allocation, and pay.
Owner’s Scorecard
Will it survive?
- Does not cover its interestOperating income $25M ÷ interest expense $29M
What this means
A full year of operating profit didn't cover the interest bill. This is the zombie zone: the business depends on refinancing, asset sales, or forbearance to service its debt.
- How heavy is the debt, net of cash? $109M · 4.4× operating profitHeavy net debtCash $111M − debt $220M
What this means
Netting $111M of cash and short-term investments against $220M of debt leaves $109M owed, about 4.4× a year's operating profit (8.9× on the gross debt, before the cash). Net debt is the leverage figure that matters: the cash is already set against the debt. Strategic or illiquid investments aren't counted here.
- Not enough data
What this means
The filing data didn't include the inputs for this check.
Is it a good business?
- Below average through the cycle6-yr median, range -79%–20%; 20% latest = NOPAT $25M ÷ invested capital $123MIndustry peers: median -37%
What this means
The rate the business earns on the money tied up in it, Buffett's north star, because over time a stock tracks the ROIC beneath it. Above ~15% sustained hints at a moat; a return below the cost of capital (~8%) erodes value as a business grows rather than building it — the test Buffett weighs most. The headline is the median of the last 6 years (it ran 20% most recently), so one peak or trough year doesn't set the verdict. Asset-light businesses (R&D expensed, little capital) read artificially high, pair this with Owner Earnings.
- SolidOwner earnings $28M = operating cash $29M − maintenance capex $1MIndustry peers: median -34%
What this means
What an owner could take out without starving the business: operating cash less the maintenance capital it must spend to hold its position — Buffett's owner earnings. That's 9% of revenue this year. Treating stock comp as the real expense it is (less $22M of SBC) leaves $5M.
- Are earnings backed by cash? 51.67×Cash-backedCash from ops $29M ÷ net income $554K
What this means
How much of reported profit showed up as operating cash. Above 1× is reassuring; well below suggests earnings lean on accruals. One year is noisy, growth and working-capital swings distort it, and this is operating cash, not free cash. Watch the multi-year trend.
How is the cash used?
- Not enough data
What this means
The filing data didn't include the inputs for this check.
- Investing or harvesting? 0.83×MaintainingCapex $1M ÷ depreciation $1M
What this means
Descriptive, not a grade. Above ~1× means investing faster than assets wear out (growth, or, sustained for years, today's earnings carrying less depreciation than tomorrow's will). Below means spending less than it's wearing out (efficiency, or a melting asset base). The ratio won't tell you which; the filings will.
Graham’s defensive tests · 1 of 5 met
Graham’s numerical criteria for the defensive investor (The Intelligent Investor, ch. 14), run on the filings. A floor of safety, not a buy signal; many fine modern businesses fail his strictest liquidity rules by design.
- Adequate size MissRevenue ≥ $2B · $292M
What this means
Big enough to weather a storm. Graham's 1972 floor was ~$100M of sales (≈ $700M today); we use a $2B revenue line as a conservative modern stand-in.
- Strong liquidity PassCurrent ratio ≥ 2× · 2.19×
What this means
Current assets at least twice current liabilities, near-term bills covered without touching the business. Strict by design: many cash-rich modern firms run leaner and miss it, holding their cushion in longer-dated securities.
- Conservative debt MissDebt ≤ working capital · $220M vs $131M WC
What this means
Graham's rule that borrowings not exceed net current assets. Capital-heavy and buyback-heavy firms routinely fail it, read it next to interest coverage, not alone.
- Earnings stability MissA profit every year (6-yr record) · 5 loss years
What this means
Graham wanted earnings in each of the past ten years, the stability a defensive owner leans on.
- Dividend record MissUninterrupted dividends · none paid
What this means
An unbroken dividend was Graham's mark of durability. He wanted twenty years; the filings show about ten, and a single suspension breaks the streak. Non-payers, many fine modern compounders, fall outside his defensive net by design.
- Earnings growth —Earnings +33% over the record · —
What this means
Earnings were negative early in the record, a growth rate isn't meaningful.
- Moderate price —P/E ≤ 15 and P/E × P/B ≤ 22.5 · decided by the price
What this means
Graham's valuation gate, the wall he kept between a sound business and a sound investment. Three-year average earnings are $-0.23/share (latest year $0.00), the averaged base the calculator's gate runs on, and book value is $0.08/share. Enter a price in “What the price implies” just below for the P/E, P/B, and whether it clears. But this is the rule Buffett outgrew: there's no hard P/E law, and a wonderful business can deserve a far richer multiple if the thesis holds, treat it as the bargain-hunter's floor, not a verdict on the price.
Durability & moat, 2020–2025
Whether the record’s returns held, and what the capital reinvested earned.
- Profitable years 1 of 6
What this means
Lost money in 5 year(s), look at what happened there before trusting the average.
- Return on capital ≥ 15% 1 of 6 yrs
What this means
A moat shows up as a high return on invested capital that holds year after year, not one good vintage.
- Operating margin −240% → −12% (3-yr avg ends)
In the filing’s words The record and the words agree: the margin widened and the filing attributes the gain to its own pricing, not volume alone.
What this means
Through the cycle the operating margin widened — about −240% early to −12% lately, median −74% — pricing power intact or improving.
- Reinvestment, incremental ROIC returns capital
What this means
The capital base barely grew: this business returns cash through dividends and buybacks rather than reinvesting. Judge it on the cash returned, not on compounding.
- Worst year 2020 · −414.5% op. margin
What this means
Operations went underwater in 2020, understand why before trusting the good years.
Does AI threaten the moat?
Low contestabilityThe moat is physical, regulated or balance-sheet-funded, the kind AI cuts costs within but does not contest.
Its FY2025 10-K names artificial intelligence as a competitive threat, in language that was not in the prior year's filing.
“Additionally, any third-party AI technologies that may be leveraged in our products and services may not be available on commercially reasonable terms, or at all, and any loss of rights to use such technologies may significantly increase our expenses or otherwise disrupt or delay the provisioning of our products and se…”
AI is unlikely to contest a moat that is physical, regulated or balance-sheet-funded; here it reads more as a cost tool than a threat.
Read from the filing's own risk factors, paired with the industry's structure under its SIC code; the durability is read above, the price below.
All figures as filed; the source filing is linked above.
Current Position
as of the latest quarter, Mar 31, 2026Can the business pay what it owes this year, off the freshest balance sheet: the quality of the assets, the debt actually coming due, and what a low ratio means here.
- Cash & short-term investments$112M
- Receivables$56M
- Inventory$74M
- Other current assets$9M
- Accounts payable$11M
- Other current liabilities$107M
From the company's latest filing.
Acquisitions & goodwill
from the balance sheet & the 6-year cash-flow recordGoodwill grows only when a company acquires and falls only when it concedes it overpaid. The size of that bet, the cash put into buying rather than building, and how much has already been written off.
None written down over the record; the goodwill is still carried at full cost. That is the deals holding their value on the books so far; whether they keep doing so is the test an owner watches, since the write-down, when it comes, is the admission the price was too high.
Goodwill, acquired intangibles and equity from the latest balance sheet; acquisition spend and write-downs summed across the 6-year record, from the company's own filings.
Management, ownership & pay
read the proxy →From the proxy: how much of the business the people running it own, and how they are paid, beside what the business earned for its owners in the same years.
| Fiscal year | Chief executive | Pay, as filed | “Actually paid” | Net income |
|---|---|---|---|---|
| 2021 | — | $3.8M | $2.3M | ($123M) |
| 2022 | — | $2.8M | $1.0M | ($95M) |
| 2023 | Mr. Edic | $2.1M | $3.5M | ($62M) |
| 2024 | — | $3.8M | $5.6M | ($55M) |
| 2024 | — | $6.8M | $8.5M | ($55M) |
| 2025 | — | $5.0M | $12.0M | $554K |
| 2025 | — | $5.0M | $12.0M | $554K |
Both pay figures are the company’s own, from the pay-versus-performance table its proxy statement files. “As filed” is the Summary Compensation Table total: salary, bonus, and equity awards at their value on the day of grant. “Actually paid” is the SEC’s prescribed recalculation, which re-marks those equity awards to what they became as they vested; it can swing far above or below the filed figure in either direction, and negative years occur. Net income is the whole business's, as filed, for the same fiscal years. A dash under the name means the filing tags the figure without naming the officer.
- Insider ownership4.4%
The stake all directors and executive officers hold together, per the 2026 proxy: skin in the game, the first thing Munger reads.
- CEO pay ratio73:1
What the chief earns for every dollar the median employee makes, per the 2026 proxy. A high ratio alone settles nothing; some businesses are genuinely top-heavy in scarce skill. A runaway figure is where Buffett starts asking whether the board is doing its job.
- Stock-based compensation$22M
The slice of the business handed to employees in shares this year, 8% of revenue, equal to 90% of operating profit. Buffett's oldest accounting fight: this is compensation, compensation is an expense, real whether or not the headline earnings admit it. One trap: the cash-flow statement adds SBC back, so the operating cash, and the owner earnings drawn from it, are flattered by exactly this amount; counted as the cost it is, what an owner keeps is lower.
Inverting the record
Invert: instead of why Xeris Biopharma Holdings Inc. is a good business, the question is what would make owning it a mistake, and whether those marks are in the record. Disconfirming tests across 2020–2025.
1 of the 3 tests turned up something to look into; the other 2 came back clean.
- Look hereDid debt outgrow the business?$87M → $221M
Debt rose from $87M to $221M while owner earnings went from about ($89M) to ($89M): the borrowing grew and the earnings that would carry it are not there now. Debt raised for buybacks or deals rather than growth is the kind that bites in a downturn.
- Is it less profitable than it was?
- Did receivables and inventory outpace sales?
Each test is read from the filings and is noisy alone; a flag can mark a cyclical trough or a year of heavy investment as easily as a problem. The filing says which.
What an owner would ask, FY2025
read the 10-K →- How much of the revenue rides on one buyer?≈$283M · 90% of revenue on the largest customers (TTM)
“As further discussed in "Note 2 - Basis of presentation and summary of significant accounting policies and estimates" to our consolidated financial statements, for the years ended December 31, 2025, 2024 and 2023, four customers accounted for over 90% of the Company's gross product revenue.”verify →
- Which reported numbers are a judgment call?Management names Revenue recognition as critical estimates
each rests partly on management's judgment; the filing's note sets out the assumptionsverify →
The questions the record and the charts do not answer on their own; each carries the figure and the place to look.
Peers, Pharmaceuticals
The same industry, side by side on owner economics. Each figure is a through-cycle median, so a peak or trough year can’t distort it; the group median at the foot is the line to read each against.
| Company | Revenue | Gross margin | Op. margin | ROIC | Owner earn. margin |
|---|---|---|---|---|---|
| CRMDCorMedix Inc. | $312M | 8% | -8961.5% | -202% | -7330% |
| EOLSEvolus Inc. | $297M | 68% | -44.0% | -142% | -34% |
| IRWDIronwood Pharmaceuticals Inc. | $296M | 94% | 27.3% | 44% | 35% |
| RIGLRigel Pharmaceuticals Inc. | $294M | 99% | -36.4% | -117% | -71% |
| XERSXeris Biopharma Holdings Inc. | $292M | — | -50.6% | -44% | 9% |
| HROWHarrow Inc. | $272M | 70% | 0.8% | -11% | -1% |
| LGNDLigand Pharmaceuticals | $268M | 96% | 31.6% | 2% | 45% |
| ARVNArvinas Inc. | $263M | — | -306.3% | -37% | -118% |
| Group median | — | — | -40.2% | -41% | -17% |
The price
What a price has to assume.
What the price implies
reverse-DCFType today's close and see the owner-earnings growth you'd have to believe to justify it, beside what Xeris Biopharma Holdings Inc. has delivered.
—
9.0% = the 4.55% 10-year Treasury (Jul 15, 2026) + 4.45 points of equity premium. The rate you require is yours to set.
Enter a price above to run it.
A dated snapshot of the price you typed, the assumptions you set, and what the page showed for them. A snapshot is never edited after it is saved. Your notebook is yours alone — the commitment states what is stored and what we will never do.
Graham capped the multiple at 15×; Buffett and Munger let that rule go: a wonderful business can deserve 50× if the thesis holds. The gate marks the bargain-hunter's floor.
Prefilled with the 10-year Treasury (4.55%, as of Jul 15, 2026). Edit it for today’s exact figure, or a AAA corporate yield.
Graham measured a stock against the bond you could own instead, the heart of his margin of safety. Enter a price above to weigh the owner-earnings yield against this bond.
Owner earnings $47M on 173M shares outstanding, per the 10-Q cover, as of 2026-04-30; net debt $109M. The base is the latest year by default; Normalize values it on the through-cycle median owner-earnings margin (to avoid paying on a peak year). Net of stock comp treats option pay as the expense it is. The dials set the multiple a growth belief justifies; the price, and every dollar on this page, is yours.
Manual order: ← XEL its page in the Manual XFOR →
Industry order: ← WVE the Pharmaceuticals chapter XNCR →