Share count
142Mpeak FY2025
← All companies ← SLMBP Manual SLNHP → ← SLGL Pharmaceuticals SNDL →
SLN, Silence Therapeutics PLC
We are a biotechnology company focused on discovering and developing novel molecules incorporating short interfering ribonucleic acid, or siRNA, to inhibit the expression of specific target genes thought to play a role in the pathology of diseases with significant unmet medical need.
By degrading the message that encodes the disease-associated protein, the production of that protein is reduced and its level of activity is lowered.
In the field of RNAi therapeutics, this reduction of disease-associated protein production and activity is referred to as "gene silencing."
The business
What it sells, where the money comes from, the kind of company it is.
Revenue · FY2025
$559K
−98.7% YoY · −70% 3-yr CAGR
Vital signs · TTM
The business in brief
read the 10-K →What this business is and what moves its needle, from its own SEC filings.
- Situation
- Unprofitable. No meaningful revenue yet; the record is the cash on hand against the burn.
- What moves the needle
- Operating margin has run around −282% through the cycle on a 59% gross margin, the operating line in the red even at its best — so the lever is whether the spending below the gross line can come down enough to clear a profit: revenue growth against the cost curve, and the cash runway until it does. Stock-based pay runs about 51% of sales, a real and recurring claim on owners that the GAAP margin understates. Read this kind of business on the pipeline against the patent cliff, and pricing. On its own account, the filing leans hardest on concentrated dependence, set against the numbers in what the filing emphasizes, below.
- Is it a good business?
- Return on capital has rarely cleared the cost of capital (median −177%, above 15% in 0 of 3 years). Owner earnings, the cash-based check, have been thin too. This is price-taker territory, where the balance sheet and the cycle matter more than any multiple; the rest is in the 10-K.
Every line is arithmetic on the company's filings, shown in full in the sections below.
The record
Ten years of arithmetic, read across the cycle.
The record, 2022–2025
realized figures from each filing · older years to the left| 2022’22 | 2023’23 | 2024’24 | 2025’25 | TTMTTMMar 2026 | |
|---|---|---|---|---|---|
| Income statement | |||||
| $22M | $32M | $43M | $559K | $839K | RevenueRevenue |
| 38% | 59% | 73% | 62% | 79% | Gross marginGross mgn |
| 119% | 83% | 62% | n/m | n/m | SG&A / revenueSG&A/rev |
| 201% | 180% | 157% | n/m | n/m | R&D / revenueR&D/rev |
| ($61M) | ($64M) | ($63M) | ($91M) | ($78M) | Operating incomeOp. inc. |
| −281.9% | −203.5% | −146.4% | n/m | n/m | Operating marginOp. mgn |
| ($50M) | ($54M) | ($45M) | ($89M) | ($75M) | Net incomeNet inc. |
| Cash flow & returns | |||||
| ($57M) | ($49M) | ($68M) | ($62M) | ($66M) | Operating cash flowOp. cash |
| $379K | $369K | $336K | $312K | $311K | DepreciationDeprec. |
| ($20M) | ($12M) | ($39M) | $18M | $2M | Working capital & otherWC & other |
| $173K | $56K | $211K | $55K | $51K | CapexCapex |
| 0.8% | 0.2% | 0.5% | 9.8% | 6.1% | Capex / revenueCapex/rev |
| ($57M) | ($50M) | ($68M) | ($62M) | ($66M) | Owner earningsOwner earn. |
| −264.2% | −156.5% | −156.9% | n/m | n/m | Owner earnings marginOE mgn |
| ($57M) | ($50M) | ($68M) | ($62M) | ($66M) | Free cash flowFCF |
| −264.2% | −156.5% | −156.9% | n/m | n/m | Free cash flow marginFCF mgn |
| -177% | — | -394% | -141% | -142% | ROICROIC |
| -185% | -247% | -34% | -142% | -152% | Return on equityROE |
| −185% | −247% | −34% | −142% | −152% | Retained to equityRetained/eq |
| Balance sheet | |||||
| — | $69M | $147M | $85M | $70M | Cash & investmentsCash+inv |
| — | $290K | $972K | $0 | $0 | ReceivablesReceiv. |
| — | $3M | $4M | $4M | $4M | Accounts payablePayables |
| — | ($3M) | ($3M) | ($4M) | ($4M) | Operating working capitalOper. WC |
| — | $103M | $187M | $119M | $103M | Current assetsCur. assets |
| — | $22M | $17M | $14M | $10M | Current liabilitiesCur. liab. |
| — | 4.6× | 11.1× | 8.7× | 9.8× | Current ratioCurr. ratio |
| $10M | $10M | $9M | $11M | $10M | GoodwillGoodwill |
| — | $119M | $203M | $131M | $115M | Total assetsAssets |
| — | ($69M) | ($147M) | ($85M) | ($70M) | Net debt / (cash)Net debt |
| $27M | $22M | $134M | $62M | $49M | Shareholders’ equityEquity |
| 58.6% | 51.4% | 37.7% | n/m | 832.1% | Stock comp / revenueSBC/rev |
| Per share | |||||
| 96.6M | 111M | 139M | 142M | 142M | Shares out (diluted)Shares |
| $0.22 | $0.28 | $0.31 | $0.00 | $0.01 | Revenue / shareRev/sh |
| $-0.52 | $-0.49 | $-0.33 | $-0.63 | $-0.53 | EPS (diluted)EPS |
| $-0.59 | $-0.44 | $-0.49 | $-0.44 | $-0.46 | Owner earnings / shareOE/sh |
| $-0.59 | $-0.44 | $-0.49 | $-0.44 | $-0.46 | Free cash flow / shareFCF/sh |
| $0.00 | $0.00 | $0.00 | $0.00 | $0.00 | Cap. spending / shareCapex/sh |
| $0.28 | $0.20 | $0.97 | $0.44 | $0.35 | Book value / shareBVPS |
Per-share growththe realized rate an owner's share compounded
| 3-yr | 5-yr | |
|---|---|---|
| Revenue / share | −74.0%/yr | −74.0%/yr (3-yr) |
| Capital spending / share | −39.9%/yr | −39.9%/yr (3-yr) |
| Book value / share | +16.0%/yr | +16.0%/yr (3-yr) |
The record, charted
FY2022–2025Each measure over its full record; the current point and the worst year marked.
ROIC
−141%low FY2024
Gross margin
62%low FY2022
Owner earnings vs. net income
Owner earningsNet incomeThe accountant's number, and the cash an owner can take; the gap is the tell.
($62M)owner earningsvs.($89M)net incomelow FY2024
Net income is the accountant's number; owner earnings is the cash an owner could take out. The walk between them, off the cash-flow statement, and whether the gap is widening or holding.
In fiscal 2025 the business turned a $89M loss into ($62M) of owner earnings: more cash than the profit line showed, after the non-cash charges and the capital it put back in.
| FY2025 | FY2024 | FY2023 | FY2022 | |
|---|---|---|---|---|
| Reported net income | ($89M) | ($45M) | ($54M) | ($50M) |
| Depreciation & amortizationnon-cash charge added back | +$312K | +$336K | +$369K | +$379K |
| Stock-based compensationreal costnon-cash, but a real cost | +$8M | +$16M | +$16M | +$13M |
| Working capital & othertiming of cash in and out, other non-cash items | +$18M | −$39M | −$12M | −$20M |
| Cash from operations | ($62M) | ($68M) | ($49M) | ($57M) |
| Capital expenditurecash put back in to keep running and to grow | −$55K | −$211K | −$56K | −$173K |
| Owner earnings | ($62M) | ($68M) | ($50M) | ($57M) |
| Owner-earnings marginowner earnings ÷ revenue | -11150% | -157% | -156% | -264% |
Owner earnings is the cash an owner could pull out without starving the business: operating cash less the capital it must spend to hold its position . The cash-flow statement also adds stock comp back as non-cash, but it is a real cost paid in shares; counted as the expense it is (less $8M), owner earnings is nearer ($70M).
Maintenance capex is estimated as depreciation where a growing business invests above it; free cash flow is the figure the scorecard's free-cash margin reads.
Quality & stewardship
Returns, the balance sheet, capital allocation, and pay.
Owner’s Scorecard
FY2025 10-K · source on SEC EDGAR →
Will it survive?
- No meaningful interest burdenLittle or no interest expense reported
What this means
Little or no interest expense reported, the business isn't leaning on lenders to operate.
- Net cash, debt-freeCash $11M + ST investments $74M − debt $0
What this means
Cash and short-term investments exceed every dollar of debt by $85M, on net the company owes nothing, and can act from strength when others can't. Net debt is the leverage figure that matters: the cash is already set against the debt. Strategic or illiquid investments aren't counted here.
- Not enough data
What this means
The filing data didn't include the inputs for this check.
Is it a good business?
- Not enough dataIndustry peers: median -64%
What this means
The filing data didn't include the inputs for this check.
- Owner-earnings margin -264%Consumes cash through the cycle4-yr median margin, range -11150%–-156%; latest ($62M) = operating cash ($62M) − maintenance capex $55KIndustry peers: median -2045%
What this means
What an owner could take out without starving the business: operating cash less the maintenance capital it must spend to hold its position — Buffett's owner earnings. That's -11150% of revenue this year, a -264% median across 4 years. Treating stock comp as the real expense it is (less $8M of SBC) leaves ($70M).
- Are earnings backed by cash? ($62M)Loss, and burning cashNet income ($89M) · cash from operations ($62M)
What this means
The company reported a net loss, so a conversion ratio isn't meaningful. What matters then is whether operations still threw off cash, here, they did not.
How is the cash used?
- Not enough data
What this means
The filing data didn't include the inputs for this check.
- Investing or harvesting? 0.18×HarvestingCapex $55K ÷ depreciation $312K
What this means
Descriptive, not a grade. Above ~1× means investing faster than assets wear out (growth, or, sustained for years, today's earnings carrying less depreciation than tomorrow's will). Below means spending less than it's wearing out (efficiency, or a melting asset base). The ratio won't tell you which; the filings will.
Graham’s defensive tests · 1 of 2 met
Graham’s numerical criteria for the defensive investor (The Intelligent Investor, ch. 14), run on the filings. A floor of safety, not a buy signal; many fine modern businesses fail his strictest liquidity rules by design.
- Adequate size MissRevenue ≥ $2B · $559K
What this means
Big enough to weather a storm. Graham's 1972 floor was ~$100M of sales (≈ $700M today); we use a $2B revenue line as a conservative modern stand-in.
- Strong liquidity PassCurrent ratio ≥ 2× · 8.72×
What this means
Current assets at least twice current liabilities, near-term bills covered without touching the business. Strict by design: many cash-rich modern firms run leaner and miss it, holding their cushion in longer-dated securities.
- Moderate price —P/E ≤ 15 and P/E × P/B ≤ 22.5 · decided by the price
What this means
Graham's valuation gate, the wall he kept between a sound business and a sound investment. Three-year average earnings are $-0.44/share (latest year $-0.63), the averaged base the calculator's gate runs on, and book value is $0.44/share. Enter a price in “What the price implies” just below for the P/E, P/B, and whether it clears. But this is the rule Buffett outgrew: there's no hard P/E law, and a wonderful business can deserve a far richer multiple if the thesis holds, treat it as the bargain-hunter's floor, not a verdict on the price.
Durability & moat, 2022–2025
Whether the record’s returns held, and what the capital reinvested earned.
- Profitable years 0 of 4
What this means
Lost money in 4 year(s), look at what happened there before trusting the average.
- Operating margin −243% → −8220% (2-yr avg ends)
What this means
Through the cycle the operating margin slipped — about −243% early to −8220% lately, median −282% — competition or costs are biting in.
- Worst year 2025 · −16292.8% op. margin
What this means
Operations went underwater in 2025, understand why before trusting the good years.
- Share count +13.6%/yr
What this means
The share count is rising, dilution works against you on a per-share basis.
Does AI threaten the moat?
Low contestabilityThe moat is physical, regulated or balance-sheet-funded, the kind AI cuts costs within but does not contest.
AI is unlikely to contest a moat that is physical, regulated or balance-sheet-funded; here it reads more as a cost tool than a threat.
Read from the filing's own risk factors, paired with the industry's structure under its SIC code; the durability is read above, the price below.
All figures as filed; the source filing is linked above.
Current Position
as of the latest quarter, Mar 31, 2026Can the business pay what it owes this year, off the freshest balance sheet: the quality of the assets, the debt actually coming due, and what a low ratio means here.
Current assets$103M
- Cash & short-term investments$70M
- Other current assets$33M
Current liabilities$10M
- Accounts payable$4M
- Other current liabilities$6M
Current ratio9.83×all current assets ÷ what's due · Graham looked for 2×
Quick ratio—inventory untagged this quarter, so withheld rather than shown equal to the current ratio
Cash ratio6.70×strictest: cash alone against what's due
Working capital$92Mthe cushion left after near-term bills
Cash runway1.1 yrsthe business is consuming cash; this is how long the cash on hand lasts at that rate
Revenue, latest quarter vs. a year ago+197.2%the freshest read on whether the business is still growing
Current ratio, recent quarters11.1× → 9.8×
Deeper floors
Tangible book value$39Mequity stripped of goodwill & intangibles
Net current asset value$37MGraham's net-net: current assets less all liabilities
Debt incl. operating leases$136K$136K of it operating leases
Deferred revenue$55Mcustomer cash collected before delivery; operating float
From the company's latest filing.
Management, ownership & pay
read the proxy →From the proxy: how much of the business the people running it own, and how they are paid, beside what the business earned for its owners in the same years.
| Fiscal year | Chief executive | Pay, as filed | “Actually paid” | Owner earnings |
|---|---|---|---|---|
| 2023 | Mr. Tooman | $9.1M | $9.7M | ($50M) |
| 2024 | Mr. Tooman | $3.7M | −$3.8M | ($68M) |
| 2025 | Iain Ross | $1.3M | $1.3M | ($62M) |
| 2025 | Mr. Tooman | $2.2M | −$1.7M | ($62M) |
Both pay figures are the company’s own, from the pay-versus-performance table its proxy statement files. “As filed” is the Summary Compensation Table total: salary, bonus, and equity awards at their value on the day of grant. “Actually paid” is the SEC’s prescribed recalculation, which re-marks those equity awards to what they became as they vested; it can swing far above or below the filed figure in either direction, and negative years occur. Owner earnings are the whole business's, from the record above, for the same fiscal years.
- Stock-based compensation$8M
The slice of the business handed to employees in shares this year, 1444% of revenue. Buffett's oldest accounting fight: this is compensation, compensation is an expense, real whether or not the headline earnings admit it. One trap: the cash-flow statement adds SBC back, so the operating cash, and the owner earnings drawn from it, are flattered by exactly this amount; counted as the cost it is, what an owner keeps is lower.
What an owner would ask, FY2025
read the 10-K →- Which reported numbers are a judgment call?Management names Revenue recognition as critical estimates
each rests partly on management's judgment; the filing's note sets out the assumptionsverify →
The questions the record and the charts do not answer on their own; each carries the figure and the place to look.
Peers, Pharmaceuticals
The same industry, side by side on owner economics. Each figure is a through-cycle median, so a peak or trough year can’t distort it; the group median at the foot is the line to read each against.
| Company | Revenue | Gross margin | Op. margin | ROIC | Owner earn. margin |
|---|---|---|---|---|---|
| DNTHDianthus Therapeutics Inc. | $2M | — | -1704.7% | -54% | -1308% |
| ORMPOramed Pharmaceuticals Inc. | $2M | 1% | -754.4% | -29% | -479% |
| STTKShattuck Labs Inc. | $1M | — | -1408.3% | -104% | -1059% |
| SLNSilence Therapeutics PLC | $559K | 60% | -242.7% | -177% | -211% |
| QUCYQuantum Cyber N.V. | $537K | 73% | -3005.0% | — | -2045% |
| DMACDiaMedica Therapeutics Inc. | $500K | — | -6879.4% | -67% | -5820% |
| MREOMereo BioPharma Group plc | $500K | — | -8021.4% | — | -6198% |
| SVRASavara Inc. | $257K | — | -6852.8% | -64% | -5624% |
| Group median | — | 60% | -2354.8% | -66% | -1676% |
The price
What a price has to assume.
What the price implies
reverse-DCFSilence Therapeutics PLC is profitable, but owner earnings are negative this year because capital spending currently outruns operating cash, a build-out, so the owner-earnings reverse-DCF has no positive base to grow. We read the price from both ends instead: type a price to see the steady-state profitability it demands, then set the mature margin you would believe and weigh the two against each other. Nothing leaves your browser unless you enter it in your notebook.
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The assumptions
Enter a price to run it.
Owner earnings it must reach—
Margin the price demands—
Owner-earnings margin today−7821%
A dated snapshot of the price you typed, the assumptions you set, and what the page showed for them. A snapshot is never edited after it is saved. Your notebook is yours alone — the commitment states what is stored and what we will never do.
Two reads of one future. From your price: the owner earnings the company must reach, valued at a mature multiple and discounted back at your rate, expressed as the margin it implies on revenue grown at your rate. From your belief: the mature margin you would credit, set on the dial above. When the margin the price demands runs above the one you would believe, you are paying for a future taken on faith. For a deep cyclical at a trough, normalized through-cycle earnings are the better lens; this mode is for the genuinely unprofitable, and for the profitable business whose capital spending currently outruns its cash.
Cite: Owner Scorecard, "Silence Therapeutics PLC (SLN), the owner's record," https://ownerscorecard.com/c/SLN, data as of 2026-07-09.
Manual order: ← SLMBP its page in the Manual SLNHP →
Industry order: ← SLGL the Pharmaceuticals chapter SNDL →